2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Cytoskeleton
  3. Microtubule/Tubulin Estrogen Receptor/ERR
  4. ER degrader 7

ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth.

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ER degrader 7 Chemical Structure

ER degrader 7 Chemical Structure

CAS No. : 2922929-63-1

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ER degrader 7 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth[1].

Molecular Weight

736.63

Formula

C33H31F4N3O5SSe
CAS No.
SMILES

O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC(F)(F)F)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ER degrader 7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER degrader 72922929-63-1ER degrader7ER degrader-7Microtubule/TubulinEstrogen Receptor/ERRcancertubulin polymerizationMCF-7T47DMCF-10ALCC2MDA-MB-231Breast cancerInhibitorinhibitorinhibit

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