ERK-IN-7

Cat. No.: HY-153350: FAQs
Data Sheet Handling Instructions

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ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC₅₀ of 5 nM and 7 nM against ERK1 and ERK2, respectively.

For research use only. We do not sell to patients.

ERK-IN-7 Chemical Structure

CAS No. : 2494010-63-6

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Biological Activity
Purity & Documentation
References
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Description

ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC₅₀ of 5 nM and 7 nM against ERK1 and ERK2, respectively^[1].

IC₅₀ & Target^[1]

ERK1

5 nM (IC₅₀)

ERK2

7 nM (IC₅₀)

In Vitro

ERK-IN-7 (Example 10; 24 h) inhibits Colo205 proliferation with an IC₅₀ of 62 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Colo205
Concentration:
Incubation Time:	24 h
Result:	Inhibited proliferation with an IC₅₀ of 62 nM.

In Vivo

ERK-IN-7 (Example 10; 2 mg/kg; i.g.) shows good pharmacokinetic results^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57 mice^[1]

Dosage:

2 mg/kg

Administration:

Intragastric administration (Pharmacokinetic Analysis)

Result:

Pharmacokinetic parameters^[1]

	C_max (ng/mL)	AUC (ng⋅h/mL)	T_1/2 (h)	MRT (h)	CL_z/F (mL/min/kg)	V_z/F (mL/kg)
ERK-IN-7 (Example 10)	1023	3441	3.66	3.47	9.69	3067

Molecular Weight

449.89

Formula

C₂₂H₂₀ClN₇O₂

CAS No.

2494010-63-6

SMILES

O=C1N2C(CN1[C@@H](C3=CC(Cl)=CC=C3)CO)=CC(C4=NC(NC5=CC=NN5C)=NC=C4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xin Li, et al. Pyrroloheterocyclic derivative, preparation method therefor, and application thereof in medicine. Patent WO2020200069A1.

ERK-IN-7 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK-IN-72494010-63-6ERKExtracellular signal regulated kinasesColo205C57 miceInhibitorinhibitorinhibit

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