2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ERK-IN-7

ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively.

For research use only. We do not sell to patients.

ERK-IN-7 Chemical Structure

ERK-IN-7 Chemical Structure

CAS No. : 2494010-63-6

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ERK-IN-7 Related Antibodies

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Description

ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively[1].

IC50 & Target[1]

ERK1

5 nM (IC50)

ERK2

7 nM (IC50)

In Vitro

ERK-IN-7 (Example 10; 24 h) inhibits Colo205 proliferation with an IC50 of 62 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ERK-IN-7 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Colo205
Concentration:
Incubation Time: 24 h
Result: Inhibited proliferation with an IC50 of 62 nM.
In Vivo

ERK-IN-7 (Example 10; 2 mg/kg; i.g.) shows good pharmacokinetic results[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57 mice[1]
Dosage: 2 mg/kg
Administration: Intragastric administration (Pharmacokinetic Analysis)
Result: Pharmacokinetic parameters[1]
Cmax (ng/mL) AUC (ng⋅h/mL) T1/2 (h) MRT (h) CLz/F (mL/min/kg) Vz/F (mL/kg)
ERK-IN-7 (Example 10) 1023 3441 3.66 3.47 9.69 3067
Molecular Weight

449.89

Formula

C22H20ClN7O2
CAS No.
SMILES

O=C1N2C(CN1[C@@H](C3=CC(Cl)=CC=C3)CO)=CC(C4=NC(NC5=CC=NN5C)=NC=C4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERK-IN-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK-IN-72494010-63-6ERKExtracellular signal regulated kinasesColo205C57 miceInhibitorinhibitorinhibit

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HY-153350
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