2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis Autophagy
  3. ERK Apoptosis Autophagy
  4. ERK1/2 inhibitor 13

ERK1/2 inhibitor 13 (Compound 21y) is the orally active inhibitor for ERK that inhibits ERK1 and ERK2 with IC50 of 91.71 nM and 97.87 nM. ERK1/2 inhibitor 13 inhibits the proliferation of MCF-7, 4T1, MDA-MB-468, and HCC1970 (IC50 of 0.67, 2.76, 2.15 and 1.68 μM), inhibits the cancer cell migration, induces apoptosis and autophagy in MCF-7. ERK1/2 inhibitor 13 exhibits antitumor and anti-metastatic effect in 4T1 xenograft mouse model.

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ERK1/2 inhibitor 13 Chemical Structure

ERK1/2 inhibitor 13 Chemical Structure

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ERK1/2 inhibitor 13 Related Antibodies

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Description

ERK1/2 inhibitor 13 (Compound 21y) is the orally active inhibitor for ERK that inhibits ERK1 and ERK2 with IC50 of 91.71 nM and 97.87 nM. ERK1/2 inhibitor 13 inhibits the proliferation of MCF-7, 4T1, MDA-MB-468, and HCC1970 (IC50 of 0.67, 2.76, 2.15 and 1.68 μM), inhibits the cancer cell migration, induces apoptosis and autophagy in MCF-7. ERK1/2 inhibitor 13 exhibits antitumor and anti-metastatic effect in 4T1 xenograft mouse model[1].

IC50 & Target

ERK1

91.71 nM (IC50)

ERK2

97.87 nM (IC50)

Molecular Weight

727.54

Formula

C36H29BrF6N4O
SMILES

O=C(N[C@@H](CC1=CC=CC=C1)CN2C3=C([N+](CC4=CC=C5C=CC=CC5=C4)=C2)C=CC=C3)NC6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6.[Br-]
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Purity & Documentation
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ERK1/2 inhibitor 13 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK1/2 inhibitor 13ERKApoptosisAutophagyExtracellular signal regulated kinases4T1MCF-7orally activeMDA-MB-468HCC1970BALB/c mouseInhibitorinhibitorinhibit

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