2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Estrogen Receptor/ERR Apoptosis
  4. ERα antagonist 1

ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells.

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ERα antagonist 1 Chemical Structure

ERα antagonist 1 Chemical Structure

CAS No. : 2762423-09-4

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ERα antagonist 1 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells[1].

IC50 & Target

ERα

 

Cellular Effect
Cell Line Type Value Description References
Ishikawa IC50
10.3 μM
Compound: 19d
Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-positive human Ishikawa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34509864]
MCF7 IC50
1.31 μM
Compound: 19d
Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34509864]
MDA-MB-231 IC50
> 50 μM
Compound: 19d
Antiproliferative activity against ER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
Antiproliferative activity against ER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay
[PMID: 34509864]
Molecular Weight

568.68

Formula

C33H32N2O5S
CAS No.
SMILES

O=C(C1=C(SC2=CC(O)=CC=C21)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OC5CN(C5)C/C=C/C(N6CCCCC6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERα antagonist 1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERα antagonist 12762423-09-4ERα antagonist1ERα antagonist-1Estrogen Receptor/ERRApoptosisMCF-7breast cancercovalent antagonistresistanceInhibitorinhibitorinhibit

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ERα antagonist 1
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HY-144733
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