2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Estrogen receptor antagonist 8

Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM).

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Estrogen receptor antagonist 8 Chemical Structure

Estrogen receptor antagonist 8 Chemical Structure

CAS No. : 2889370-92-5

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Estrogen receptor antagonist 8 Related Antibodies

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Description

Estrogen receptor antagonist 8 is a potent ER-antagonist with in vivo anti-uterotrophic potential (EC50 = 4.160 μM).

IC50 & Target[1]

Estrogen receptor

 

In Vivo

In an in vivo anti-uterotrophic assay, a dose-response curve set by measuring the reduction of uterus weight of immature female rats when compared to the control group.
Anti-uterotrophic assay of ER-antagonist (compound 4) (s.c.; 1, 3, 10, 20, 30 mg/Kg/day; 3 days) exhibits an excelled anti-uterotrophic potential than TMX (EC50: 7.625 μM), the EC50 value of ER-antagonist 8 is 4.160 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

427.45

Formula

C25H21N3O4
CAS No.
SMILES

COC(C=C1)=CC(CCC2=C3C4=CC=C(C=C4)OC)=C1C2=NN3C5=CC=C([N+]([O-])=O)C=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Estrogen receptor antagonist 8 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estrogen receptor antagonist 82889370-92-5Estrogen receptor antagonist8Estrogen receptor antagonist-8Estrogen Receptor/ERRInhibitorinhibitorinhibit

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HY-143267
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