2. GPCR/G Protein
  3. CaSR
  4. Etelcalcetide hydrochloride

Etelcalcetide hydrochloride  (Synonyms: Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride)

Cat. No.: HY-P1955A Purity: 99.61%
COA Handling Instructions

Molarity Calculator

Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Etelcalcetide hydrochloride Chemical Structure

Etelcalcetide hydrochloride Chemical Structure

CAS No. : 1334237-71-6

Size Price Stock Quantity
1 mg USD 40 In-stock
5 mg USD 85 In-stock
10 mg USD 130 In-stock
25 mg USD 250 In-stock
50 mg USD 420 In-stock
100 mg USD 690 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Etelcalcetide hydrochloride:

Etelcalcetide hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Etelcalcetide hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].
In Vitro

Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etelcalcetide hydrochloride Related Antibodies
In Vivo

Etelcalcetide hydrochloride (2.5 µg/h and 20 µg/h, infusion, 3 days) significantly reduces plasma PTH concentrations and decreased the renal expression of Cyp24a1 with a higher delivery rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL7/6J male mice
Dosage: 2.5 µg/h and 20 µg/h
Administration: infusion, 3 days
Result: Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 µg/h, but decreased the renal expression of Cyp24a1 with 20 µg/h [1]
Clinical Trial
Molecular Weight

1353.33

Formula

C38H73N21O10S2.17/2HCl
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

C1' . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1'-Cys1)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (73.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7389 mL 3.6946 mL 7.3892 mL
5 mM 0.1478 mL 0.7389 mL 1.4778 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (73.89 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.61%

COA (258 KB) RP-HPLC (245 KB) MS (177 KB) Elemental Analysis Report (117 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7389 mL 3.6946 mL 7.3892 mL 18.4730 mL
5 mM 0.1478 mL 0.7389 mL 1.4778 mL 3.6946 mL
10 mM 0.0739 mL 0.3695 mL 0.7389 mL 1.8473 mL
15 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2315 mL
20 mM 0.0369 mL 0.1847 mL 0.3695 mL 0.9236 mL
25 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7389 mL
30 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
40 mM 0.0185 mL 0.0924 mL 0.1847 mL 0.4618 mL
50 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3695 mL
60 mM 0.0123 mL 0.0616 mL 0.1232 mL 0.3079 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Etelcalcetide hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etelcalcetide1334237-71-6VelcalcetideAMG 416KAI-4169AMG416AMG-416KAI4169KAI 4169CaSRCalcium-sensing receptorsecondary hyperparathyroidismchronic kidney diseasecalcimimeticPTHInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Etelcalcetide hydrochloride
Cat. No.:
HY-P1955A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.