Etelcalcetide  (Synonyms: Velcalcetide; AMG 416; KAI-4169)

Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease^[1][2].

Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etelcalcetide hydrochloride (2.5 µg/h and 20 µg/h, infusion, 3 days) significantly reduces plasma PTH concentrations and decreased the renal expression of Cyp24a1 with a higher delivery rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1048.25

C₃₈H₇₃N₂₁O₁₀S₂

1262780-97-1

C1' . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1'-Cys1)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. [1]Van Megen WH, et al. Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1[J]. EBioMedicine. 2022 Apr;78:103947.  [Content Brief]

  [2]. Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403.  [Content Brief]