Ethybenztropine  (Synonyms: Ponalid; UK 738)

Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent^[1].

Muscarinic Receptor^[1]

Ethybenztropine (10 μM) inhibits the uptake of ³H-DA in neostriatal slices.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits^[1].
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs^[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

321.46

C₂₂H₂₇NO

524-83-4

CCN([C@@H](CC1)C2)[C@H]1C[C@@H]2OC(C3=CC=CC=C3)C4=CC=CC=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10.  [Content Brief]

  [2]. M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6.  [Content Brief]

  [3]. LARS-OVE FARNEBO, et al. Effect of some antiparkinsonian drugs on catecholamine neurons. Journal of Pharmacy and Pharmacology, 1970, 22(10): 733-737.