Ethylmalonic acid-d₃

Name: Ethylmalonic acid-d 3
Brand: MedChemExpress
SKU: HY-34740S
Rating: 4.5 (1 reviews)

Cat. No.: HY-34740S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ethylmalonic acid-d₃ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

For research use only. We do not sell to patients.

Ethylmalonic acid-d<sub>3</sub> Chemical Structure

Ethylmalonic acid-d₃ Chemical Structure

CAS No. : 70907-93-6

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Ethylmalonic acid-d₃:

Ethylmalonic acid In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

135.13

Formula

C₅H₅D₃O₄

CAS No.

70907-93-6

Unlabeled CAS

601-75-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(CC([2H])([2H])[2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1850.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4003 mL	37.0014 mL	74.0028 mL
5 mM	1.4801 mL	7.4003 mL	14.8006 mL
10 mM	0.7400 mL	3.7001 mL	7.4003 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Gregersen N, et al. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91 [Content Brief]

[3]. Yano S, et al. A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy. Eur J Pediatr. 1997 May;156(5):382-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	7.4003 mL	37.0014 mL	74.0028 mL	185.0070 mL
	5 mM	1.4801 mL	7.4003 mL	14.8006 mL	37.0014 mL
	10 mM	0.7400 mL	3.7001 mL	7.4003 mL	18.5007 mL
	15 mM	0.4934 mL	2.4668 mL	4.9335 mL	12.3338 mL
	20 mM	0.3700 mL	1.8501 mL	3.7001 mL	9.2504 mL
	25 mM	0.2960 mL	1.4801 mL	2.9601 mL	7.4003 mL
	30 mM	0.2467 mL	1.2334 mL	2.4668 mL	6.1669 mL
	40 mM	0.1850 mL	0.9250 mL	1.8501 mL	4.6252 mL
	50 mM	0.1480 mL	0.7400 mL	1.4801 mL	3.7001 mL
	60 mM	0.1233 mL	0.6167 mL	1.2334 mL	3.0835 mL
	80 mM	0.0925 mL	0.4625 mL	0.9250 mL	2.3126 mL
	100 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8501 mL