2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. Etiocholanolone-d5

Etiocholanolone-d5 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

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Etiocholanolone-d<sub>5</sub> Chemical Structure

Etiocholanolone-d5 Chemical Structure

CAS No. : 1620102-33-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Etiocholanolone-d5:

Etiocholanolone-d5 Related Antibodies

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Description

Etiocholanolone-d5 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Etiocholanolone-d5 Related Antibodies
Molecular Weight

295.47

Formula

C19H25D5O2
CAS No.
Unlabeled CAS

53-42-9
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])C2)([2H])O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (169.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3844 mL 16.9222 mL 33.8444 mL
5 mM 0.6769 mL 3.3844 mL 6.7689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3844 mL 16.9222 mL 33.8444 mL 84.6110 mL
5 mM 0.6769 mL 3.3844 mL 6.7689 mL 16.9222 mL
10 mM 0.3384 mL 1.6922 mL 3.3844 mL 8.4611 mL
15 mM 0.2256 mL 1.1281 mL 2.2563 mL 5.6407 mL
20 mM 0.1692 mL 0.8461 mL 1.6922 mL 4.2305 mL
25 mM 0.1354 mL 0.6769 mL 1.3538 mL 3.3844 mL
30 mM 0.1128 mL 0.5641 mL 1.1281 mL 2.8204 mL
40 mM 0.0846 mL 0.4231 mL 0.8461 mL 2.1153 mL
50 mM 0.0677 mL 0.3384 mL 0.6769 mL 1.6922 mL
60 mM 0.0564 mL 0.2820 mL 0.5641 mL 1.4102 mL
80 mM 0.0423 mL 0.2115 mL 0.4231 mL 1.0576 mL
100 mM 0.0338 mL 0.1692 mL 0.3384 mL 0.8461 mL
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Etiocholanolone-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etiocholanolone-d51620102-33-1GABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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