Evolocumab  (Synonyms: AMG 145)

Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation^[1][2][3].

Human IgG2 lambda

Human

PCSK9^[1]

Evolocumab (5-100 μg/mL) can significantly prevent the cytotoxicity of H₂O₂ on human umbilical vein endothelial cells (HUVEC)[2].
Evolocumab (100 μg/mL) can reduce the expression and secretion of inflammatory factors increased by stimulation of rat retinal Müller cells (RMC)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1256937-27-5

Liquid

Colorless to light yellow

[Evolocumab]

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG2 lambda

• [1]. Fala L, et, al. Repatha (Evolocumab): Second PCSK9 Inhibitor Approved by the FDA for Patients with Familial Hypercholesterolemia. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):136-9.  [Content Brief]

  [2]. Zhou Q, et al. Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions. J Diabetes Complications. 2023 Oct;37(10):108593.  [Content Brief]

  [3]. Safaeian L, et al. Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H2O2-induced oxidative stress. Arch Physiol Biochem. 2022 Dec;128(6):1681-1686.  [Content Brief]