2. Apoptosis
  3. Paraptosis
  4. fac-[Re(CO)3(L3)(H2O)][NO3]

fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy.

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fac-[Re(CO)3(L3)(H2O)][NO3] Chemical Structure

fac-[Re(CO)3(L3)(H2O)][NO3] Chemical Structure

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fac-[Re(CO)3(L3)(H2O)][NO3] Related Antibodies

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Description

fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy[1].

In Vivo

fac-[Re(CO)3(L3)(H2O)][NO3]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

715.64

Formula

C25H17N6O8Re
SMILES

[OH2][Re+]1([N]2=CC=CC3=C2C4=C(C5=C3N=C(C6=CNC7=C6C=C(OC)C=C7)N5)C=CC=[N]41)([C]=O)([C]=O)[C]=O.[O-][N+]([O-])=O
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Room temperature in continental US; may vary elsewhere.
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fac-[Re(CO)3(L3)(H2O)][NO3] Related Classifications

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Keywords:

fac-[Re(CO)3(L3)(H2O)][NO3]ParaptosisInhibitorinhibitorinhibit

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