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  4. Farletuzumab

Farletuzumab  (Synonyms: MORAb-003)

Cat. No.: HY-P99153 Purity: ≥95.0%
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Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No. : 896723-44-7

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10 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Farletuzumab Related Antibodies

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Description

Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer[1].

Isotype

Human IgG1(E356D/M358L) kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Farletuzumab (MORAb-003; 0-10 μg/mL; CHO-FR cells) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner[1].
Farletuzumab (0.1-100 μg/mL; IGROV-1 cells; 1 h) mediates tumor cytotoxicity via complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro[1].
Farletuzumab (0-10 μg/mL; CHO-FR cells) inhibits phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby, blocking a FRa-mediated signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Farletuzumab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: IGROV-1 cells
Concentration: 0.1, 1, 10, and 100 µg/mL
Incubation Time: 1 hours
Result: Had significant cytotoxicity at IGROV-1 cells.
Clinical Trial
Molecular Weight

145360.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Farletuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Farletuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farletuzumab896723-44-7MORAb-003MORAb003MORAb 003Antibiotichumanized monoclonal antibodyfolate receptor-alphaanticancerCHO-FR cellsIGROV-1 cellsInhibitorinhibitorinhibit

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