2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. Fasiglifam hemihydrate

Fasiglifam hemihydrate  (Synonyms: TAK-875 hemihydrate)

Cat. No.: HY-W010655
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Fasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury.

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Fasiglifam hemihydrate Chemical Structure

Fasiglifam hemihydrate Chemical Structure

CAS No. : 1374598-80-7

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Fasiglifam hemihydrate Related Antibodies

Top Publications Citing Use of Products

    Fasiglifam hemihydrate purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Jul 11;13(7):e0200449.  [Abstract]

    TAK-875 increases (p<0.05) the membrane expression of FFAR1 compared to the untreated control by 97%.

    Fasiglifam hemihydrate purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2017 May;118(5):1249-1261.  [Abstract]

    Free fatty acid receptor 1 (FFAR1) agonist induces LOX-1 upregulation in cultured vascular smooth muscle cells (VSMCs). Cultured VSMCs are treated with synthetic agonists for either FFAR1 (TAK-875) or FFAR4 (TUG-891) at indicated doses for 24 hours. Both FFAR1 and FFAR4 are known responsible for long chain fatty acids. 0.1% DMSO is used as solvent control (SC). Western blotting detection indicates that treatment with agonistic action of FFAR1, but not FFAR4, remarkably upregulated LOX-1 expressi

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    Description

    Fasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury[1][2][3][4].

    IC50 & Target

    EC50: 72 nM (GPR40)[1]
    Molecular Weight

    533.63

    Formula

    C29H33O7.5S
    CAS No.
    SMILES

    CC1=C(C(C)=CC(OCCCS(C)(=O)=O)=C1)C2=CC(COC3=CC=C4[C@@H](COC4=C3)CC(O)=O)=CC=C2.[0.5H2O]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Fasiglifam hemihydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fasiglifam hemihydrate1374598-80-7TAK-875 hemihydrateFree Fatty Acid ReceptorFFARdiabeticliver injuryinsulinhyperglycemiaInhibitorinhibitorinhibit

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