2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR-IN-14

FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC50s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC50s of 19, 59, and 73 nM, respectively.

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FGFR-IN-14 Chemical Structure

FGFR-IN-14 Chemical Structure

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FGFR-IN-14 Related Antibodies

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Description

FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1, FGFR2, FGFR3 and FGFR2 V564F gatekeeper mutant with IC50s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC50s of 19, 59, and 73 nM, respectively[1].

Molecular Weight

475.45

Formula

C24H19F2N7O2
SMILES

CC(N1)=NC2=C1C=C(F)C(C#CC3=NN(CC4=CC=CC(NC(C=C)=O)=C4)C(N)=C3C(N)=O)=C2F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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FGFR-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-14FGFRFibroblast growth factor receptorPan-FGFRNCI-H520SNU-16KATO IIIgastric cancer cellsInhibitorinhibitorinhibit

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