FGFR-IN-7

Cat. No.: HY-147684: FAQs
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FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

FGFR-IN-7 Chemical Structure

CAS No. : 2488764-17-4

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Description	FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research^[1].
In Vivo	FGFR-IN-7 (compound 17) (1 mg/kg, Orally, once daily for 10 days) significantly enhances recovery of coordinated movement in the in vivo rat acute stroke model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	374.81
Formula	C₁₆H₂₁ClF₂N₄O₂
CAS No.	2488764-17-4
SMILES	CN(C1CCN(CC1)CC2CC2(F)F)C(COC3=CC=C(N=N3)Cl)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562. [Content Brief]

FGFR-IN-7 Related Classifications

Neurological Disease

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-72488764-17-4FGFRFibroblast growth factor receptorfibroblast growth factor receptorFGFR modulatorPhospholipidosisP-gpneuroprotective activityneurodegenerative diseasesheterocyclic pyrimidine derivativeInhibitorinhibitorinhibit

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FGFR-IN-7

FGFR-IN-7 Related Antibodies

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