2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-20

FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC50s of 19 and 36 nM against Huh7 cells and FGFR4 enzyme. FGFR4-IN-20 can be used for hepatocellular carcinoma research.

For research use only. We do not sell to patients.

FGFR4-IN-20 Chemical Structure

FGFR4-IN-20 Chemical Structure

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FGFR4-IN-20 Related Antibodies

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Description

FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC50s of 19 and 36 nM against Huh7 cells and FGFR4 enzyme. FGFR4-IN-20 can be used for hepatocellular carcinoma research[1].

IC50 & Target

FGFR4

 

In Vitro

FGFR4-IN-20 (0.01-1000 nM) shows IC50s of 19, 16 and 33 nM against Huh7 (FGFR4 overexpression), Hep3B (FGF19 amplification) and JHH-7 (FGF19 amplification) cell lines, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FGFR4-IN-20 Related Antibodies
In Vivo

FGFR4-IN-20 (100mg/kg, p.o., QD for 15 d) significantly reduces the tumor volumes of ICR mice without a loss of body weight or other clinical signs[1].
1.19
Pharmacokinetics Profile of FGFR4-IN-20 in ICR Mice[1]

Parameter IV (5 mg/kg) PO (100 mg/kg, QD)
AUC0-24 (ng·h/mL) 4810 59534
Cmax (ng/mL) 8137 24566
Tmax (h) 0.5
T1/2 (h) 1.7 3.9
F% 61.9

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

509.38

Formula

C26H22Cl2N4O3
SMILES

ClC1=C(C2=CC3=CN=C(C=C3C(C)=N2)NC4=C(C=CC=C4)NC(C=C)=O)C(Cl)=C(OC)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FGFR4-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-20FGFRFibroblast growth factor receptorHuh7Hep3BJHH-7FGFR4hepatocellular carcinomaInhibitorinhibitorinhibit

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FGFR4-IN-20
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HY-163569
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