Fibronectin Adhesion-promoting Peptide TFA  (Synonyms: Heparin Binding Peptide TFA)

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells^[1][2][3].

GRGDS and Fibronectin Adhesion-promoting Peptide TFA (Heparin Binding Peptide TFA: WQPPRARI) micropatterns increase the endothelialisation of prosthetic materials in vitro. Fibronectin Adhesion-promoting Peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif^[1].
RDGS and Fibronectin Adhesion-promoting Peptide TFA promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1137.22

C₄₉H₇₅F₃N₁₆O₁₂

Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile

WQPPRARI

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• [1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.  [Content Brief]

  [2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.  [Content Brief]

  [3]. Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29(4):878-884.  [Content Brief]