FITC-Lithocholic acid 3-sulfate  (Synonyms: FITC-Sulfolithocholic acid)

FITC-Lithocholic acid 3-sulfate (FITC-Sulfolithocholic acid) is a FITC-labeled Lithocholic acid 3-sulfate, which is a sulfated biliary metabolite. Lithocholic acid 3-sulfate selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate can be used for the research of pathogenesis of cholestatic liver diseases^[1].

888.10

C₄₇H₅₇N₃O₁₀S₂

Solid

Light yellow to yellow

C[C@H](CCC(NCCNC(NC1=CC=C(C2=C(C=C3)C(OC4=C2C=CC(O)=C4)=CC3=O)C(C(O)=O)=C1)=S)=O)[C@H]5CC[C@@]6([H])[C@]7([H])CC[C@]8([H])C[C@H](OS(=O)(O)=O)CC[C@]8(C)[C@@]7([H])CC[C@]56C

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Xiao R, et al. Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation. J Leukoc Biol. 2022 Oct;112(4):835-843.  [Content Brief]