FLDP-5

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FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells.

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FLDP-5 Chemical Structure

CAS No. : 950665-12-0

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	3.9 μM Compound: 14	Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay Antiproliferative activity against rat C6 cells after 72 hrs by MTT assay	[PMID: 20831222]
Caco-2	IC₅₀	0.2 μM Compound: 14	Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay Antiproliferative activity against human Caco-2 cells after 72 hrs by MTT assay	[PMID: 20831222]
HaCaT	IC₅₀	3 μM Compound: 14	Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells after 72 hrs by MTT assay	[PMID: 20831222]
HT-22	IC₅₀	3.1 μM Compound: 14	Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay Antiproliferative activity against mouse HT22 cells after 72 hrs by MTT assay	[PMID: 20831222]
NB-4	IC₅₀	0.4 μM Compound: 231	Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay Cytotoxicity against human NB4 cells assessed as reduction in cell viability after 72 hrs by MTS assay	[PMID: 24960549]
NIH3T3	IC₅₀	4.2 μM Compound: 14	Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay Antiproliferative activity against BALB/c mouse 3T3 cells after 72 hrs by MTT assay	[PMID: 20831222]
SH-SY5Y	IC₅₀	2.1 μM Compound: 14	Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 20831222]

In Vitro

FLDP-5 (0-20 μM; 24 h) has cytotoxicity on human glioblastoma multiforme (GBM) LN-18 cells and HBEC-5i^[1].
FLDP-5 (2.5 μM; 0-6 h) induces superoxide and hydrogen peroxide in LN-18 cell death^[1].
FLDP-5 (2.5 μM; 0-4 h) induces DNA damage with a time-dependent manner in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 and 48 h) potentiates anti-migration effects in LN-18 cells^[1].
FLDP-5 (1.25 and 2.5 μM; 24 h) reduces the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner^[1].
FLDP-5 (0.625 and 1.25 μM; 24 h) induces arrest in S phase in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	LN-18 and HBEC-5i cells
Concentration:	0-20 μM
Incubation Time:	24 h
Result:	Exhibited cytotoxicity on human GBM LN-18 cells and HBEC-5i with IC₅₀s of 2.4 μM and 5.6 μM.

Cell Migration Assay ^[1]

Cell Line:	LN-18 cells
Concentration:	1.25 and 2.5 μM
Incubation Time:	24 and 48 h
Result:	Potentiated anti-migration effects in LN-18 cells with wound closure of 56.43% ± 6.28 and 3.17% ± 0.71 at 1.25 μM and 2.5 μM (48 h), respectively.

Cell Invasion Assay^[1]

Cell Line:	LN-18 cells
Concentration:	1.25 and 2.5 μM
Incubation Time:	24 h
Result:	Reduced the percentage of relative invasion in LN-18 cells in a significant dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:	LN-18 cells
Concentration:	0.625 and 1.25 μM
Incubation Time:	24 h
Result:	Induced arrest in S phase in a concentration-dependent manner, and exhibited accumulation of 63.38% ± 4.42 at 1.25 μM.

Molecular Weight

367.40

Formula

C₂₁H₂₁NO₅

CAS No.

950665-12-0

SMILES

O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Razali NSC, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12(1):13131. [Content Brief]

FLDP-5 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLDP-5950665-12-0FLDP5FLDP 5Reactive Oxygen SpeciesDNA/RNA SynthesisAnticancerLN-18glioblastoma multiformeDNA damagetumouranti-proliferativeanti-migratoryInhibitorinhibitorinhibit

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