FLS-359 

FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC₅₀ of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication^[1].

FLS-359 (0-100 μM) inhibits deacetylation of SIRT2 on a histone H3 site, with a substrate selectivity^[1].
FLS-359 inhibits growth of multiple RNA and DNA virus, like SARS-CoV-2, Influenza A, Hepatitis B, respiratory syncytial virus, with IC₅₀ range of 0.3-6.7 μM^[1].
FLS-359 (0-10 μM, 24 h) inhibits the lytic activation of Epstein-Barr virus (EBV) in cells Akata, and the spread of human cytomegalovirus (HCMV) in diploid fibroblast with IC₅₀ of 0.466 μM^[1].
FLS-359 (0-5 μM, 72 h) inhibits the accumulation of intracellular viral nucleic acids, the production of extracellular virus particles, and the infectivity of the virus particles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLS-359 (50 mg/kg, p.o., single dose) exhibits a good plasma exposure with a plasma half-life of 6 h, maximal plasma concentrations C_max of 89 μM and an AUC of 713 μM•h/mL^[1].
FLS-359 (50 mg/kg, p.o., twice daily for 11 days) inhibits HCMV infection in immunodeficient mice model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

466.60

C₂₇H₂₆N₆S

2309398-79-4

CC1=CN(C(C)=N1)C2=CC=C3CCN(CC3=C2)C4=NC=C(S4)CC5=CC=C(C=C5)N6C=CC=N6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Roche KL, et al., An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J Clin Invest. 2023 Jun 15;133(12):e158978.  [Content Brief]