2. Protein Tyrosine Kinase/RTK NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. FLT3 Reactive Oxygen Species Apoptosis
  4. FLT3-IN-29

FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity.

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FLT3-IN-29 Chemical Structure

FLT3-IN-29 Chemical Structure

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FLT3-IN-29 Related Antibodies

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Description

FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity[1].

In Vitro

FLT3-IN-29 shows good antiproliferative activity against MV4-11 cells (IC50 = 0.59 μM)[1].
FLT3-IN-29 (0.2-10 μM, 24 h) arrests cell cycle at the G0/G1 phase, induces•apoptosis, and reduces ROS levels in MV4-11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3-IN-29 Related Antibodies
Molecular Weight

446.54

Formula

C25H30N6O2
SMILES

CC(C)N1CCC(NC2=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C(C(N)=O)C=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLT3-IN-29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-29FLT3Reactive Oxygen SpeciesApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3AntiproliferativeMV4-11A549HCT116Antileukemic.Inhibitorinhibitorinhibit

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