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  4. Fludarabine-Cl

Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases.

For research use only. We do not sell to patients.

Fludarabine-Cl Chemical Structure

Fludarabine-Cl Chemical Structure

CAS No. : 2734853-80-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
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Based on 1 publication(s) in Google Scholar

Fludarabine-Cl Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases[1].

IC50 & Target

ADAR1

0.87 μM (IC50)

In Vitro

Fludarabine-Cl inhibits tumor cell proliferation, and has only a weak inhibitory effect on normal RWPE1 and HEK293 cells. The IC50 for MDA-MB-23, RPMI822, HL60 and K562 is 0.383, 0.149, 0.544 and 0.609 μM[1].
Fludarabine-Cl binds to ADAR1 protein with a KD of 7.24 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fludarabine-Cl Related Antibodies
In Vivo

Fludarabine-Cl (104.9-400 mg/kg, intraperitoneal injection, twice a day, for one day) has some toxicity in mice, with an LD50 of 186.5641 mg/kg[1].
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day
Administration: Intraperitoneal injection (i.p.)
Result: Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs.
Animal Model: BALB/c mice induced by Du-145[1]
Dosage: 10, 20 mg/kg; twice a day; 29 days
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and had no effect on mouse body weight.
Molecular Weight

303.68

Formula

C10H11ClFN5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2C(N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CCl)C=N2)=NC(F)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (16.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2929 mL 16.4647 mL 32.9294 mL
5 mM 0.6586 mL 3.2929 mL 6.5859 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (6.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2929 mL 16.4647 mL 32.9294 mL 82.3235 mL
5 mM 0.6586 mL 3.2929 mL 6.5859 mL 16.4647 mL
10 mM 0.3293 mL 1.6465 mL 3.2929 mL 8.2324 mL
15 mM 0.2195 mL 1.0976 mL 2.1953 mL 5.4882 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fludarabine-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fludarabine-Cl2734853-80-4OthersRNA adenosine deaminaseADAR1cancertumor-related diseasesInhibitorinhibitorinhibit

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