Fludarabine triphosphate trisodium (Synonyms: F-ara-ATP trisodium)

Name: Fludarabine triphosphate trisodium
Brand: MedChemExpress
SKU: HY-136650A
Rating: 4.5 (1 reviews)

Cat. No.: HY-136650A Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.

For research use only. We do not sell to patients.

Fludarabine triphosphate trisodium Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 390	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 390	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1700	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Fludarabine triphosphate trisodium:

Fludarabine triphosphate Get quote

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Description

IC₅₀ & Target

IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)^[1]

In Vitro

Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells^[1].
Fludarabine triphosphate trisodium (10-50 μM) inhibits the incorporation of ATP into primer RNA and dTTP into DNA to a similar extent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

591.12

Formula

C₁₀H₁₂FN₅Na₃O₁₃P₃

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(F)=NC(N)=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (211.46 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6917 mL	8.4585 mL	16.9170 mL
5 mM	0.3383 mL	1.6917 mL	3.3834 mL
10 mM	0.1692 mL	0.8459 mL	1.6917 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (252 KB) HNMR (309 KB) MS (489 KB)

Handling Instructions (2659 KB)

References

[1]. Catapano CV, et al. Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. Cancer Res. 1991 Apr 1;51(7):1829-35. [Content Brief]

[2]. Woodahl EL, et al. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb;63(3):391-401. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.6917 mL	8.4585 mL	16.9170 mL	42.2926 mL
	5 mM	0.3383 mL	1.6917 mL	3.3834 mL	8.4585 mL
	10 mM	0.1692 mL	0.8459 mL	1.6917 mL	4.2293 mL
	15 mM	0.1128 mL	0.5639 mL	1.1278 mL	2.8195 mL
	20 mM	0.0846 mL	0.4229 mL	0.8459 mL	2.1146 mL
	25 mM	0.0677 mL	0.3383 mL	0.6767 mL	1.6917 mL
	30 mM	0.0564 mL	0.2820 mL	0.5639 mL	1.4098 mL
	40 mM	0.0423 mL	0.2115 mL	0.4229 mL	1.0573 mL
	50 mM	0.0338 mL	0.1692 mL	0.3383 mL	0.8459 mL
	60 mM	0.0282 mL	0.1410 mL	0.2820 mL	0.7049 mL
	80 mM	0.0211 mL	0.1057 mL	0.2115 mL	0.5287 mL
	100 mM	0.0169 mL	0.0846 mL	0.1692 mL	0.4229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Fludarabine triphosphate trisodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fludarabine triphosphate trisodiumF-ara-ATP trisodiumNucleoside Antimetabolite/AnalogDrug MetaboliteDNA/RNA SynthesisApoptosischronic lymphocytic leukemiahematopoietic cell transplantationCCRF-CEM cellsATPapoptosisDNA primaseDNA polymeraseInhibitorinhibitorinhibit

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Fludarabine triphosphate trisodium (Synonyms: F-ara-ATP trisodium)

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Complete Stock Solution Preparation Table

Fludarabine triphosphate trisodium Related Classifications

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