2. Anti-infection Apoptosis
  3. Fungal Apoptosis
  4. Fludioxonil

Fludioxonil  (Synonyms: CGA-173506)

Cat. No.: HY-W021040 Purity: 99.94%
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Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.

For research use only. We do not sell to patients.

Fludioxonil Chemical Structure

Fludioxonil Chemical Structure

CAS No. : 131341-86-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 190 In-stock
100 mg USD 285 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fludioxonil:

Fludioxonil Related Antibodies

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Description

Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].

In Vitro

Fludioxonil with EC50 of Fludioxonil for HA61, NT18 and SZ45 are 0.0039, 0.0118 and 0.018 lg/mL[1].
Fludioxonil has a strong inhibitory effect on hyphal growth[1].
Fludioxonil (10 nM-10 μM, 9 days) promots the proliferation of MCF-7 CV cells[2].
Fludioxonil (10 μM, 72 h) reduces the expression of p21 and E-cadherin proteins in MCF-7 CV cells[2].
Fludioxonil (10 μM, 72 h) promotes the migration of MCF-7 CV cells[2].
Fludioxonil inhibits F98 cells with an IC50 of 40μM[3].
Fludioxonil (10-40 μM, 24 h) increases ROS levels in F98 cells and induces lipid peroxidation and cell cycle arrest[3].
Fludioxonil (10-40 μM, 24 h) treatment induces DNA fragmentation in F98 cells[3].
Fludioxonil (10-40 μM, 24 h) treatment induces apoptosis in F98 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fludioxonil Related Antibodies

Cell Viability Assay[2]

Cell Line: MCF-7 CV
Concentration: 10 nM, 1 μM, 10 μM
Incubation Time: 9 days
Result: Promoted cell proliferation.

Western Blot Analysis[2]

Cell Line: MCF-7 CV
Concentration: 10 μM
Incubation Time: 72 h
Result: Reduced p21 expression and significantly increased protein expression of cyclin E1 and cyclin D1.

Cell Migration Assay [2]

Cell Line: MCF-7 CV
Concentration: 10 μM
Incubation Time: 72 h
Result: Enabled significant single-layer wound healing.
In Vivo

Fludioxonil (40 mg/kg, i.g., once every three days for 80 days) inhibits tumor proliferation in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7V-transplanted mice[2]
Dosage: 40 mg/kg; every 3 days; 80 days
Administration: i.g.
Result: Accelerated tumor growth in vivo, and the expression of PCNA in animal tumor tissues also significantly increased.
Molecular Weight

248.19

Formula

C12H6F2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CNC=C1C2=C3OC(F)(F)OC3=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (805.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0292 mL 20.1460 mL 40.2920 mL
5 mM 0.8058 mL 4.0292 mL 8.0584 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

COA (253 KB) HNMR (118 KB) RP-HPLC (197 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0292 mL 20.1460 mL 40.2920 mL 100.7301 mL
5 mM 0.8058 mL 4.0292 mL 8.0584 mL 20.1460 mL
10 mM 0.4029 mL 2.0146 mL 4.0292 mL 10.0730 mL
15 mM 0.2686 mL 1.3431 mL 2.6861 mL 6.7153 mL
20 mM 0.2015 mL 1.0073 mL 2.0146 mL 5.0365 mL
25 mM 0.1612 mL 0.8058 mL 1.6117 mL 4.0292 mL
30 mM 0.1343 mL 0.6715 mL 1.3431 mL 3.3577 mL
40 mM 0.1007 mL 0.5037 mL 1.0073 mL 2.5183 mL
50 mM 0.0806 mL 0.4029 mL 0.8058 mL 2.0146 mL
60 mM 0.0672 mL 0.3358 mL 0.6715 mL 1.6788 mL
80 mM 0.0504 mL 0.2518 mL 0.5037 mL 1.2591 mL
100 mM 0.0403 mL 0.2015 mL 0.4029 mL 1.0073 mL
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Fludioxonil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fludioxonil131341-86-1CGA-173506CGA173506CGA 173506FungalApoptosisBactericidaltumor growth promotingapoptosis promotingcardiotoxicInhibitorinhibitorinhibit

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