Fluralaner-¹³C₂,¹⁵N,d₃  (Synonyms: A1443-¹³C₂,¹⁵N,d₃; AH252723-¹³C₂,¹⁵N,d₃)

Fluralaner-¹³C₂,¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

562.28

C₂₀¹³C₂H₁₄D₃Cl₂F₆N₂¹⁵NO₃

864731-61-3

Solid

White to off-white

O=C([15NH][13CH2][13C](NCC(F)(F)F)=O)C1=CC=C(C2=NOC(C(F)(F)F)(C3=C([2H])C(Cl)=C([2H])C(Cl)=C3[2H])C2)C=C1C

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]

  [2]. Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275.  [Content Brief]

  [3]. Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.  [Content Brief]