2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. FM-479

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

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FM-479 Chemical Structure

FM-479 Chemical Structure

CAS No. : 2226521-64-6

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Based on 1 publication(s) in Google Scholar

FM-479 Related Antibodies

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Description

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

IC50 & Target

JAK3

 

In Vitro

FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FM-479 Related Antibodies
Molecular Weight

442.51

Formula

C25H26N6O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.2%

SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References
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FM-479 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FM-4792226521-64-6FM479FM 479JAKJanus kinasenegativecontrolJAK3FM-381kinasecovalentreversibleInhibitorinhibitorinhibit

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