Fmoc-Ala-Ala-Asn(Trt)-OH

Name: Fmoc-Ala-Ala-Asn(Trt)-OH
Brand: MedChemExpress
SKU: HY-130933
Rating: 4.5 (1 reviews)

Cat. No.: HY-130933 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Ala-Ala-Asn(Trt)-OH Chemical Structure

CAS No. : 1951424-92-2

Size	Price	Stock	Quantity
1 mg	USD 315	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

738.83

Formula

C₄₄H₄₂N₄O₇

CAS No.

1951424-92-2

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](NC([C@@H](NC([C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C)=O)C)=O)CC(NC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Stored under nitrogen, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (169.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3535 mL	6.7675 mL	13.5349 mL
5 mM	0.2707 mL	1.3535 mL	2.7070 mL
10 mM	0.1353 mL	0.6767 mL	1.3535 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB) HNMR (308 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3535 mL	6.7675 mL	13.5349 mL	33.8373 mL
	5 mM	0.2707 mL	1.3535 mL	2.7070 mL	6.7675 mL
	10 mM	0.1353 mL	0.6767 mL	1.3535 mL	3.3837 mL
	15 mM	0.0902 mL	0.4512 mL	0.9023 mL	2.2558 mL
	20 mM	0.0677 mL	0.3384 mL	0.6767 mL	1.6919 mL
	25 mM	0.0541 mL	0.2707 mL	0.5414 mL	1.3535 mL
	30 mM	0.0451 mL	0.2256 mL	0.4512 mL	1.1279 mL
	40 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8459 mL
	50 mM	0.0271 mL	0.1353 mL	0.2707 mL	0.6767 mL
	60 mM	0.0226 mL	0.1128 mL	0.2256 mL	0.5640 mL
	80 mM	0.0169 mL	0.0846 mL	0.1692 mL	0.4230 mL
	100 mM	0.0135 mL	0.0677 mL	0.1353 mL	0.3384 mL