Fmoc-Hyp(Bom)-OH 

Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

539.58

C₂₈H₃₃N₃O₈

187223-15-0

Solid

White to pink

O=C(O)[C@@H]1C[C@@H](OC(NCCNC(OC(C)(C)C)=O)=O)CN1C(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.  [Content Brief]

  [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.  [Content Brief]