2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-N-methyl-PEG3-CH2CH2COOH

Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-N-methyl-PEG3-CH2CH2COOH Chemical Structure

Fmoc-N-methyl-PEG3-CH2CH2COOH Chemical Structure

CAS No. : 1807518-77-9

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Fmoc-N-methyl-PEG3-CH2CH2COOH Related Antibodies

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Description

Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable Linker

 

Alkyl/ether

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-N-methyl-PEG3-CH2CH2COOH Related Antibodies
Molecular Weight

457.52

Formula

C25H31NO7
CAS No.
SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)N(C)CCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fmoc-N-methyl-PEG3-CH2CH2COOH Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-N-methyl-PEG3-CH2CH2COOH1807518-77-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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