2. PROTAC
  3. PROTAC Linkers
  4. Fmoc-N-PEG7-acid

Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-N-PEG7-acid Chemical Structure

Fmoc-N-PEG7-acid Chemical Structure

CAS No. : 1863885-74-8

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250 mg USD 141 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Fmoc-N-PEG7-acid Related Antibodies

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  • Purity & Documentation

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Description

Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-N-PEG7-acid Related Antibodies
Molecular Weight

619.70

Formula

C32H45NO11
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

OC(CCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6137 mL 8.0684 mL 16.1368 mL
5 mM 0.3227 mL 1.6137 mL 3.2274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.52%

SDS (252 KB)

COA (240 KB) HNMR (126 KB) LCMS (292 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6137 mL 8.0684 mL 16.1368 mL 40.3421 mL
5 mM 0.3227 mL 1.6137 mL 3.2274 mL 8.0684 mL
10 mM 0.1614 mL 0.8068 mL 1.6137 mL 4.0342 mL
15 mM 0.1076 mL 0.5379 mL 1.0758 mL 2.6895 mL
20 mM 0.0807 mL 0.4034 mL 0.8068 mL 2.0171 mL
25 mM 0.0645 mL 0.3227 mL 0.6455 mL 1.6137 mL
30 mM 0.0538 mL 0.2689 mL 0.5379 mL 1.3447 mL
40 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0086 mL
50 mM 0.0323 mL 0.1614 mL 0.3227 mL 0.8068 mL
60 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6724 mL
80 mM 0.0202 mL 0.1009 mL 0.2017 mL 0.5043 mL
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Fmoc-N-PEG7-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-N-PEG7-acid1863885-74-8PROTAC LinkersInhibitorinhibitorinhibit

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