2. PROTAC
  3. PROTAC Linkers
  4. Fmoc-NH-PEG12-CH2CH2COOH

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG12-CH2CH2COOH Chemical Structure

Fmoc-NH-PEG12-CH2CH2COOH Chemical Structure

CAS No. : 1952360-91-6

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250 mg USD 31 In-stock
1 g USD 123 In-stock
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Based on 1 publication(s) in Google Scholar

Fmoc-NH-PEG12-CH2CH2COOH Related Antibodies

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Description

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-NH-PEG12-CH2CH2COOH Related Antibodies
Molecular Weight

839.96

Formula

C42H65NO16
CAS No.
Appearance

Liquid (Density: 1.175±0.06 g/cm3)

Color

Light yellow to light brown

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (119.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1905 mL 5.9527 mL 11.9053 mL
5 mM 0.2381 mL 1.1905 mL 2.3811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (239 KB) HNMR (133 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1905 mL 5.9527 mL 11.9053 mL 29.7633 mL
5 mM 0.2381 mL 1.1905 mL 2.3811 mL 5.9527 mL
10 mM 0.1191 mL 0.5953 mL 1.1905 mL 2.9763 mL
15 mM 0.0794 mL 0.3968 mL 0.7937 mL 1.9842 mL
20 mM 0.0595 mL 0.2976 mL 0.5953 mL 1.4882 mL
25 mM 0.0476 mL 0.2381 mL 0.4762 mL 1.1905 mL
30 mM 0.0397 mL 0.1984 mL 0.3968 mL 0.9921 mL
40 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7441 mL
50 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.5953 mL
60 mM 0.0198 mL 0.0992 mL 0.1984 mL 0.4961 mL
80 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3720 mL
100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2976 mL
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Fmoc-NH-PEG12-CH2CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-NH-PEG12-CH2CH2COOH1952360-91-6PROTAC LinkersInhibitorinhibitorinhibit

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