2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Fmoc-NH-PEG9-CH2CH2COOH

Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Fmoc-NH-PEG9-CH2CH2COOH Chemical Structure

Fmoc-NH-PEG9-CH2CH2COOH Chemical Structure

CAS No. : 1191064-81-9

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Fmoc-NH-PEG9-CH2CH2COOH Related Antibodies

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Description

Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-NH-PEG9-CH2CH2COOH Related Antibodies
Molecular Weight

707.80

Formula

C36H53NO13
CAS No.
Appearance

Liquid (Density: 1.186 g/cm3)

Color

Colorless to off-white

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 97.34%

COA (240 KB) HNMR (117 KB) LCMS (352 KB)

Handling Instructions (2659 KB)
References
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Fmoc-NH-PEG9-CH2CH2COOH Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-NH-PEG9-CH2CH2COOH1191064-81-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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