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  3. Amino Acid Derivatives
  4. Fmoc-Pen(Trt)-OH

Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II.

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Fmoc-Pen(Trt)-OH Chemical Structure

Fmoc-Pen(Trt)-OH Chemical Structure

CAS No. : 201531-88-6

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Based on 1 publication(s) in Google Scholar

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Description

Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II[1].

Molecular Weight

613.76

Formula

C39H35NO4S
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (162.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6293 mL 8.1465 mL 16.2930 mL
5 mM 0.3259 mL 1.6293 mL 3.2586 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

SDS (394 KB)

COA (254 KB) HNMR (136 KB) RP-HPLC (261 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6293 mL 8.1465 mL 16.2930 mL 40.7325 mL
5 mM 0.3259 mL 1.6293 mL 3.2586 mL 8.1465 mL
10 mM 0.1629 mL 0.8147 mL 1.6293 mL 4.0733 mL
15 mM 0.1086 mL 0.5431 mL 1.0862 mL 2.7155 mL
20 mM 0.0815 mL 0.4073 mL 0.8147 mL 2.0366 mL
25 mM 0.0652 mL 0.3259 mL 0.6517 mL 1.6293 mL
30 mM 0.0543 mL 0.2716 mL 0.5431 mL 1.3578 mL
40 mM 0.0407 mL 0.2037 mL 0.4073 mL 1.0183 mL
50 mM 0.0326 mL 0.1629 mL 0.3259 mL 0.8147 mL
60 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6789 mL
80 mM 0.0204 mL 0.1018 mL 0.2037 mL 0.5092 mL
100 mM 0.0163 mL 0.0815 mL 0.1629 mL 0.4073 mL
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Fmoc-Pen(Trt)-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Pen(Trt)-OH201531-88-6Amino Acid DerivativesProtecting groupspeptide synthesisderivativesamino acidsInhibitorinhibitorinhibit

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