1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Fonsartan free acid

Fonsartan free acid  (Synonyms: HOE-720 free acid)

Cat. No.: HY-119379
Handling Instructions

Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases.

For research use only. We do not sell to patients.

Fonsartan free acid Chemical Structure

Fonsartan free acid Chemical Structure

CAS No. : 144628-52-4

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Description

Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases[1].

Molecular Weight

544.69

Formula

C26H32N4O5S2

CAS No.
SMILES

O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(NC(NCCC)=O)=O)C=CC=C3)C=C2)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Fonsartan free acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Fonsartan free acid
Cat. No.:
HY-119379
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