Fosbretabulin (Synonyms: Combretastatin A4 phosphate)

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Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors.

For research use only. We do not sell to patients.

Fosbretabulin Chemical Structure

CAS No. : 222030-63-9

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Other In-stock Forms of Fosbretabulin:

Fosbretabulin disodium

Other Forms of Fosbretabulin:

Fosbretabulin disodium In-stock
Fosbretabulin tromethamine Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A10	EC₅₀	7 nM Compound: CA4P	Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique	[PMID: 20973488]
DU-145	GI₅₀	0.00336 μM Compound: CA4P	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28217276]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay	10.1039/C6MD00360E
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27597243]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay	[PMID: 27592394]
HCT-116	IC₅₀	0.042 μM Compound: CA-4P	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
HeLa	IC₅₀	4.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells by sulforhodamine B assay Antiproliferative activity against human HeLa cells by sulforhodamine B assay	[PMID: 20973488]
HeLa	IC₅₀	5.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay	[PMID: 20973488]
MGC-803	IC₅₀	0.02 μM Compound: CA-4P	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
NCI-H460	GI₅₀	0.00282 μM Compound: CA4P	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28217276]
PC-3	IC₅₀	0.033 μM Compound: CA-4P	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
SK-OV-3	GI₅₀	0.0019 μM Compound: CA4P	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 28217276]
SK-OV-3	IC₅₀	4.5 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay	[PMID: 20973488]
SK-OV-3	IC₅₀	6.6 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay	[PMID: 20973488]

Molecular Weight

396.33

Formula

C₁₈H₂₁O₈P

CAS No.

222030-63-9

SMILES

O=P(O)(O)OC1=C(C=CC(/C=C\C2=CC(OC)=C(C(OC)=C2)OC)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mooney, et al. "A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome." Thyroid 19.3 (2009): 233-240. [Content Brief]

Fosbretabulin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosbretabulin222030-63-9Combretastatin A4Combretastatin A 4Combretastatin A-4ApoptosisMicrotubule/TubulinVascular damagemicrotubule polymerizationapoptosisthyroid cancerInhibitorinhibitorinhibit

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Fosbretabulin (Synonyms: Combretastatin A4 phosphate)

Other Forms of Fosbretabulin:

Fosbretabulin Related Antibodies

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

Fosbretabulin Related Classifications

Molarity Calculator

Dilution Calculator