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FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC50 value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis.

For research use only. We do not sell to patients.

FPPS-IN-2 Chemical Structure

FPPS-IN-2 Chemical Structure

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FPPS-IN-2 Related Antibodies

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Description

FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC50 value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis[1].

IC50 & Target

IC50: 1.108 µM (HFPPS)[1]
In Vivo

FPPS-IN-2 (compound 4a) (0.1, 1, 10 mg/kg; p.o.; daily for 8 weeks) shows antiosteoporosis efficacy in ovariectomized rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g, Female Wistar rats[1]
Dosage: 0.1, 1, 10 mg/kg
Administration: P.o.; daily for 8 weeks
Result: Increased the osteocalcin level only with the 1, and 10 mg/kg doses, reduced urinary calcium.
Molecular Weight

410.46

Formula

C24H26O6
SMILES

COC1=CC(/C=C/C(C)=O)=CC=C1OCCOC2=CC=C(/C=C/C(C)=O)C=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FPPS-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPPS-IN-2Othersorally activeovariectomized ratsosteoporosisInhibitorinhibitorinhibit

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FPPS-IN-2
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HY-163832
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