2. GPCR/G Protein
  3. Formyl Peptide Receptor (FPR)
  4. FPR-A14

FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation.

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FPR-A14 Chemical Structure

FPR-A14 Chemical Structure

CAS No. : 329691-12-5

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5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 320 In-stock
50 mg USD 545 In-stock
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Based on 1 publication(s) in Google Scholar

FPR-A14 Related Antibodies

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Description

FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].

In Vitro

FPR-A14 (compound 14) activates Ca2+ release with an EC50 of 630 nM in human neutrophils. FPR-A14 is a neutrophil chemoattractant and dose-dependently induces neutrophil migration with an EC50 value of 42 nM[1].
FPR-A14 (1-10 μM; 48h) elicites a significant increase in % cell differentiation versus controls at concentrations of 4μM (32.0%), 6μM (64.9%), 8μM (89.1%) and 10μM (93.3%) in mouse neuroblastoma N2a cells. FPRa14 (100μM) produces similar effects in IMR-32 and SH-SY5Y cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FPR-A14 Related Antibodies
Molecular Weight

404.42

Formula

C23H20N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(OCO2)C2=C1)N/N=C/C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (309.08 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4727 mL 12.3634 mL 24.7268 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4727 mL 12.3634 mL 24.7268 mL 61.8169 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL 12.3634 mL
10 mM 0.2473 mL 1.2363 mL 2.4727 mL 6.1817 mL
15 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1211 mL
20 mM 0.1236 mL 0.6182 mL 1.2363 mL 3.0908 mL
25 mM 0.0989 mL 0.4945 mL 0.9891 mL 2.4727 mL
30 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
40 mM 0.0618 mL 0.3091 mL 0.6182 mL 1.5454 mL
50 mM 0.0495 mL 0.2473 mL 0.4945 mL 1.2363 mL
60 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0303 mL
80 mM 0.0309 mL 0.1545 mL 0.3091 mL 0.7727 mL
100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.6182 mL
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FPR-A14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPR-A14329691-12-5Formyl Peptide Receptor (FPR)NeutrophilCa2+chemotaxiscell differentiationN2a cellneutrophilsIMR-32SH-SY5YInhibitorinhibitorinhibit

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