2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Soclenicant

Soclenicant  (Synonyms: BNC210; IW-2143)

Cat. No.: HY-172236 Purity: 99.75%
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Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders.

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Soclenicant Chemical Structure

Soclenicant Chemical Structure

CAS No. : 1020634-41-6

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Description

Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders[1][2][3][4].

In Vivo

Soclenicant (BNC210) (0.1-10 mg/kg) increases the time spent and the distance travelled in the open arms of the maze in mice[4].

Mean pharmacokinetic parameters following oral administration of Soclenicant (BNC210) to male Sprague Dawley rats at doses of 0.5, 5 and 100 mg/kg[3]

Parameter Measured Dose (mg/kg) Apparent thalf (h) Cmax (μM) Tmax (min) AUC0-tlast (μM*min) AUC0-inf (μM*min) AUC0-inf/D (μM*min*kg/μmol) Apparent BA (%) % Dose in urine
0.5 mg/kg 0.55 c.n.c. 0.2 30 53.8 c.n.c. 41.4 66.7 1.6
5 mg/kg 4.8 8.8 1.1 30/300/30 496.8 497.6 43.7 70.3 0.7
100 mg/kg 102.4 6.3 5.7 150 3055.1 3062.9 12.5 13.2 0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

418.49

Formula

C24H26N4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(NC3CC4=C(C3)C=CC=C4)=CN=C2N(CC)C=C1C(N5CCOCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Soclenicant Related Classifications

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Keywords:

Soclenicant1020634-41-6BNC210 IW-2143BNC 210BNC-210IW2143IW 2143IW-2143nAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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