2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. FR186054

FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis.

For research use only. We do not sell to patients.

FR186054 Chemical Structure

FR186054 Chemical Structure

CAS No. : 179053-90-8

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FR186054 Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT

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Description

FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis[1][2].

Molecular Weight

489.66

Formula

C26H27N5OS2
CAS No.
SMILES

O=C(N(CC1=CC=CC(C2=NNC=C2)=C1)CC3=CC=CC=C3)NC4=C(SC)N=C(C)C=C4SC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FR186054 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR186054179053-90-8FR 186054FR-186054AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasehypercholesterolemiaatherosclerosisin cholesterol-fed ratsInhibitorinhibitorinhibit

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HY-117466
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