2. Metabolic Enzyme/Protease Apoptosis
  3. Fat Mass and Obesity-associated Protein (FTO) Apoptosis
  4. FTO-IN-14

FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models.

For research use only. We do not sell to patients.

FTO-IN-14 Chemical Structure

FTO-IN-14 Chemical Structure

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FTO-IN-14 Related Antibodies

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Description

FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models[1].

IC50 & Target

IC50: FTO (0.45 μM)
Molecular Weight

393.50

Formula

C22H23N3O2S
SMILES

OC(C(SC=C1)=C1NC2=C(C3CC3)C=C(C4=C(C)NN=C4C)C=C2C5CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FTO-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTO-IN-14Fat Mass and Obesity-associated Protein (FTO)Apoptosisacute myeloid leukemiaAMLMOLM13NB4HELOCI-AML3MV4-11MONOMAC6Balb/c mouseInhibitorinhibitorinhibit

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