2. Metabolic Enzyme/Protease
  3. FXR
  4. FXR agonist 12

FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models.

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FXR agonist 12 Chemical Structure

FXR agonist 12 Chemical Structure

CAS No. : 1831862-88-4

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FXR agonist 12 Related Antibodies

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Description

FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models[1].

Molecular Weight

404.63

Formula

C26H44O3
CAS No.
SMILES

C[C@@]12[C@]3([H])[C@]([C@@H]([C@@H]([C@]1([H])CCCC2)CC)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C
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FXR agonist 12 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FXR agonist 121831862-88-4FXR agonist12FXR agonist-12FXRNR1H4NASHcholestasisnon-alcoholic fatty liver diseaseorally activeInhibitorinhibitorinhibit

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