G6PI 325-339 (human)

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G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

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G6PI 325-339 (human) Chemical Structure

CAS No. : 1174631-35-6

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Other Forms of G6PI 325-339 (human):

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Description	G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms^[1].
In Vivo	G6PI can be used to induce arthritis models. Induction of Arthritis^[2] Background G6PI is capable of producing antibodies in the body that induce arthritis by inducing immunoactive cells to produce cytokines (such as TNF-α, IL-1β). Specific Mmodeling Methods Mice: DAB/1 • 6-10 week old Administration: 50 μg in complete Freund's adjuvant • s.c. at the base of the tail • single dose Note (1) DBA/1 mice were bred and maintained under specific-pathogen free conditions in our animal facility. (2) Mice were sacrificed on day 12 after immunization and single-cell suspensions from draining lymph nodes were prepared. Modeling Indicators Morphology: Showed a strong synovialitis and inflammation of the adjacent skeletal muscle , which was dominated by neutrophilic granulocytes as a sign of acute inflammation and exhibited activation of synovial fibroblasts to a lesser extent. The synovial tissue was enlarged due to the dense inflammatory infiltrate; however, bone destruction was onlyfocally observed. Molecular changes: Increased the levels of IL-17, TNFα, RANKL, and IFNγ. Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808) Opposite Product(s): / MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	1801.12
Formula	C₈₂H₁₁₇N₁₉O₂₁S₃
CAS No.	1174631-35-6
Sequence	Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu
Sequence Shortening	IWYINCFGCETHAML
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Angela Pizzolla, et al. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Am J Pathol. 2013 Oct;183(4):1144-1155. [Content Brief] [2]. Bruns L, et al. Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther. 2009;11(4):R117. [Content Brief]