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  4. Gadoterate meglumine

Gadoterate meglumine  (Synonyms: Gd-DOTA; Magnescope; P-449)

Cat. No.: HY-108760 Purity: 99.86%
SDS COA Handling Instructions Technical Support

Gadoterate meglumine (Gd-DOTA) is a non-specific paramagnetic gadolinium complex used as a contrast enhancer in magnetic resonance imaging (MRI). Gadoterate meglumine, as a contrast agent in MRI, is able to shorten the longitudinal relaxation time (T1) of tissue, resulting in a brighter signal in MRI images. Gadoterate meglumine can be used for the study of the central nervous system (such as the brain and spinal cord), abdominal, pelvic organs, breast, bone and joint imaging, angiography, and cardiac electrophysiology.

For research use only. We do not sell to patients.

Gadoterate meglumine Chemical Structure

Gadoterate meglumine Chemical Structure

CAS No. : 92943-93-6

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Description

Gadoterate meglumine (Gd-DOTA) is a non-specific paramagnetic gadolinium complex used as a contrast enhancer in magnetic resonance imaging (MRI). Gadoterate meglumine, as a contrast agent in MRI, is able to shorten the longitudinal relaxation time (T1) of tissue, resulting in a brighter signal in MRI images. Gadoterate meglumine can be used for the study of the central nervous system (such as the brain and spinal cord), abdominal, pelvic organs, breast, bone and joint imaging, angiography, and cardiac electrophysiology[1].

Molecular Weight

753.86

Formula

C23H42GdN5O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC.O=C1[O-][Gd+3]234([O-]5)([O-]6)([O-]7)[N]8(CC[N]2(CC[N]3(CC[N]4(CC8)CC7=O)CC6=O)CC5=O)C1.[H+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (265.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3265 mL 6.6325 mL 13.2651 mL
5 mM 0.2653 mL 1.3265 mL 2.6530 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

SDS (393 KB)

COA (258 KB) RP-HPLC (250 KB) MS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3265 mL 6.6325 mL 13.2651 mL 33.1627 mL
5 mM 0.2653 mL 1.3265 mL 2.6530 mL 6.6325 mL
10 mM 0.1327 mL 0.6633 mL 1.3265 mL 3.3163 mL
15 mM 0.0884 mL 0.4422 mL 0.8843 mL 2.2108 mL
20 mM 0.0663 mL 0.3316 mL 0.6633 mL 1.6581 mL
25 mM 0.0531 mL 0.2653 mL 0.5306 mL 1.3265 mL
30 mM 0.0442 mL 0.2211 mL 0.4422 mL 1.1054 mL
40 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8291 mL
50 mM 0.0265 mL 0.1327 mL 0.2653 mL 0.6633 mL
60 mM 0.0221 mL 0.1105 mL 0.2211 mL 0.5527 mL
80 mM 0.0166 mL 0.0829 mL 0.1658 mL 0.4145 mL
100 mM 0.0133 mL 0.0663 mL 0.1327 mL 0.3316 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gadoterate92943-93-6Gd-DOTA Magnescope P-449P449P 449P-449Biochemical Assay ReagentsContrast mediaparamagnetismrelaxation timeMRIcardiac electrophysiologyJoint imagingInhibitorinhibitorinhibit

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