Gallinamide A

Cat. No.: HY-N10109: FAQs
Data Sheet Handling Instructions

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Gallinamide A is a potent inhibitor of cathepsin L with an IC₅₀ value of 17.6 pM.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Gallinamide A TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

Gallinamide A Chemical Structure

CAS No. : 1208232-55-6

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of Gallinamide A:

Gallinamide A TFA Get quote

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Biological Activity
Purity & Documentation
References
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Description

Gallinamide A is a potent inhibitor of cathepsin L with an IC₅₀ value of 17.6 pM.

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	34.6 μM Compound: 1	Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay	[PMID: 30006166]
A-375	IC₅₀	45.6 μM Compound: 1	Antiproliferative activity against human A375 cells after 48 hrs by MTT assay Antiproliferative activity against human A375 cells after 48 hrs by MTT assay	[PMID: 30006166]
A549	IC₅₀	40.4 μM Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30006166]
B16-F10	IC₅₀	59.7 μM Compound: 1	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 30006166]
MCF7	IC₅₀	45.5 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30006166]
MDA-MB-231	IC₅₀	34.9 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 30006166]
PANC-1	IC₅₀	31.2 μM Compound: 1	Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay	[PMID: 30006166]
Vero C1008	CC₅₀	> 100 μM Compound: 1; GalA	Cytotoxicity against cells African green monkey Vero E6 cells incubated for 24 to 72 hrs by alamar blue assay Cytotoxicity against cells African green monkey Vero E6 cells incubated for 24 to 72 hrs by alamar blue assay	[PMID: 34730959]

Molecular Weight

592.77

Formula

C₃₁H₅₂N₄O₇

CAS No.

1208232-55-6

SMILES

CC[C@H](C)[C@H](N(C)C)C(O[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)/C=C/C(N1[C@H](C(OC)=CC1=O)C)=O)=O)=O)=O

Structure Classification

Others

Initial Source

Microorganisms

marine cyanobacterium?Schizothrix?sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ashhurst AS, et al. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv [Preprint]. 2020 Dec 24:2020.12.23.424111. [Content Brief]

Gallinamide A Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gallinamide A1208232-55-6SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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