Gallinamide A TFA

Cat. No.: HY-N10109A Purity: 99.85%: FAQs
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Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM).

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Gallinamide A TFA Chemical Structure

CAS No. : 1352920-57-0

Size	Price	Stock	Quantity
1 mg	USD 533	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3366	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5050	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Gallinamide A TFA:

Gallinamide A Get quote

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description	Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM)^[1]^[2].
IC₅₀ & Target	IC50: 17.6 pM (Cathepsin L); 7.34 nM (Cathepsin B); 697 nM (Cathepsin V); 79.6 nM (Cathepsin K); 367 pM (Cathepsin S)^[1] EC50: 28 nM (SARS-CoV-2)^[1] IC50: 50 nM (P. falciparum)^[2]
In Vitro	Gallinamide A TFA has low cytotoxicity with CC₅₀ >100 μM in VeroE6 cells. Gallinamide A TFA (0.5 μM; 96 h) can inhibit CatL-mediated SARS-CoV-2 endosome entry into VeroE6 cells^[1]. Gallinamide A TFA also mesylate with the TMPRSS2 inhibitor Nafamostat (HY-B0190A) exhibits synergistic effects. Potent antiviral activity in HEK-ACE2-TMPRSS2 cells, but ineffective in VeroE6 cell line^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Gallinamide A TFA Related Antibodies
Molecular Weight	706.79
Formula	C₃₃H₅₃F₃N₄O₉
CAS No.	1352920-57-0
Appearance	Solid
Color	White to off-white
SMILES	CC[C@H](C)[C@H](N(C)C)C(O[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)/C=C/C(N1[C@H](C(OC)=CC1=O)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
Structure Classification	Others
Initial Source	Microorganisms marine cyanobacterium Schizothrix sp.
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.85% Select Batch: Data Sheet (269 KB) SDS (252 KB) COA (249 KB) HNMR (237 KB) CNMR (233 KB) RP-HPLC (263 KB) LCMS (138 KB) Handling Instructions (2659 KB)
References	[1]. Ashhurst AS, et al. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv [Preprint]. 2020 Dec 24:2020.12.23.424111. [Content Brief] [2]. Stoye A, et al. Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. 2019 Jun 13;62(11):5562-5578. [Content Brief]