2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. gamma-secretase modulator 1

γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

For research use only. We do not sell to patients.

gamma-secretase modulator 1 Chemical Structure

gamma-secretase modulator 1 Chemical Structure

CAS No. : 1172637-87-4

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Based on 1 publication(s) in Google Scholar

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Description

γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

Cellular Effect
Cell Line Type Value Description References
H4 IC50
44 nM
Compound: 15
Inhibition of gamma secretase in human H4 cells overexpressing human APP assessed as reduction in amyloid beta-42 secretion after 22 hrs
Inhibition of gamma secretase in human H4 cells overexpressing human APP assessed as reduction in amyloid beta-42 secretion after 22 hrs
[PMID: 21924610]
Molecular Weight

416.54

Formula

C24H24N4OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CN(C2=CC=C(C=C2OC)NC3=NC4=C(S3)CCCC4C5=CC=CC=C5)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Purity & Documentation
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gamma-secretase modulator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

gamma-secretase modulator 11172637-87-4γ-secretaseGamma secretaseInhibitorinhibitorinhibit

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gamma-secretase modulator 1
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HY-10043
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