Ganomycin I

Cat. No.: HY-N10076: FAQs
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Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects.

For research use only. We do not sell to patients.

Ganomycin I Chemical Structure

CAS No. : 1191255-15-8

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Description	Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects^[1]^[2].
Molecular Weight	342.43
Formula	C₂₁H₂₆O₄
CAS No.	1191255-15-8
SMILES	OC1=C(C=C(C=C1)O)[C@@]2([H])C=C(C(O2)=O)CC/C=C(C)/CC/C=C(C)/C
Structure Classification	Phenols Polyphenols
Initial Source	Microorganisms Ganoderma colossum
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Tran PT, et, al. Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1. Phytomedicine. 2019 Mar 1;55:1-8. [Content Brief] [2]. Wang K, et, al. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem. 2018 Apr 26;61(8):3609-3625. [Content Brief]

Ganomycin I Related Classifications

Metabolic Disease Infection

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganomycin I1191255-15-8HMG-CoA Reductase (HMGCR)GlucosidaseHIV Proteaseα-GlucosidaseHMG-CoA reductaseanti-diabeticanti-osteoclastogenesisInhibitorinhibitorinhibit

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Ganomycin I

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