2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Garetosmab

Garetosmab  (Synonyms: REGN 2477)

Cat. No.: HY-P99632 Purity: ≥95.0%
COA

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Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research.

For research use only. We do not sell to patients.

CAS No. : 2097125-54-5

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1 mg USD 400 In-stock
5 mg USD 1040 In-stock
10 mg USD 1650 In-stock
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Based on 1 publication(s) in Google Scholar

Garetosmab Related Antibodies

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Description

Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Garetosmab (REGN 2477) specifically binds to and blocks signaling of activin proteins containing the inhibin βα subunit (activins A, AB, and AC). In vitro, Garetosmab has high affinity and specificity for activins A, AB, and AC, but does not bind or functionally inhibit other TGF-β family ligands that share the same activin receptor pathways, including activin B, inhibin A, BMP-2, BMP6, BMP9, BMP10, GDF8, and GDF11[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Garetosmab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Garetosmab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation

Purity: ≥95.0%

COA (291 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Garetosmab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garetosmab2097125-54-5REGN 2477REGN2477REGN-2477TGF-β ReceptorTransforming growth factor beta receptorsActivin Ahuman IgG4 monoclonal antibodyfibrodysplasia ossificans progressiva,Inhibitorinhibitorinhibit

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