TMEM170B - transmembrane protein 170B Gene

Homo sapiens

Gene ID: 100113407 | Gene type: protein coding

About TMEM170B

This gene has 1 transcript (splice variant), 200 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 11.1), brain (RPKM 9.1) and 21 other tissues.

Summary

Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM170B Products(1)

mRNA	Protein	Name
NM_001100829.3	NP_001094299.1	transmembrane protein 170B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29367600	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29367600	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	29367600	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM170B Protein Structure

Tmemb_170

0
100
132 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 170B

Related Diseases

Diseases

Alias

Orofacial Cleft 1

OFC1	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1
Orofacial Cleft, Nonsyndromic	Ofc
Cleft Lip/Palate, Nonsyndromic	Orofacial Cleft-1
Nonsyndromic Cleft Lip With Or Without Cleft Palate 1	Nonsyndromic Cleft Lip Palate
Otofaciocervical Syndrome 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14681	TMEM170B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TMEM170B	MGD	MGI:3647046
Felis catus	TMEM170B	VGNC	VGNC:102537
Rattus norvegicus	TMEM170B	RGD	RGD:1561506
Macaca mulatta	TMEM170B	VGNC	VGNC:104435
Canis familiaris	TMEM170B	VGNC	VGNC:54375
Bos taurus	TMEM170B	VGNC	VGNC:54241

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